Anhydro-X

/// PRODUCT DESCRIPTION

Anhydro-X is a sophisticated and innovative formula with 6 plant extracts, based on the latest research on fat burning and weight management. It contains Caffeine combined with EnXtra™ Blue Ginger extract, the ultimate caffeine amplifier. Innovative in weight management are fat blocker Curcuma extract and Olive extract that improves insulin sensitivity. The formula is completed with Vitamins B3 & B6 and Chromium Picolinate. These ingredients interact synergistically and Black Pepper ensures an efficient uptake to give an optimal result.

The human body has two types of fat, Brown Adipose Tissue, or brown fat, and White Adipose Tissue, or white fat. The main function of brown fat is to turn food into body heat and is often referred as the “good” fat as it burns calories. This process of energy creating is called thermogenesis. White fat cells on the contrary, are the result of excess calorie intake and are storing energy. We typically find these white cells in the waist and thigh area. White fat cells can convert in brown fat cells and also start to burn energy instead of storing it. Anhydro-X contains a blend of 10 synergistically interacting ingredients which helps in weight management.

Suited for:

• Persons that want to reduce their fat percentage

• Athletes that need to lose weight due to weight categories in their sport

• Body builders during prep- and depletion phase

• Overweight or obese persons that want to change their body composition

/// RECOMMENDED USE

On Training Days: take 2 caps (=1 serving) in the morning on an empty stomach and 2 caps +/- 20 minutes before your workout.

On Non-Training days: take 2 caps in the morning on an empty stomach and 2 caps in the early afternoon (contains 317mg Caffeine).

/// ACTIVE INGREDIENTS PER DAILY SERVING (4 Vcaps)

EGCG (extracted from Green Tea) and Caffeine

Both the catechin Epigallocatechin Gallate (EGCG)⁽¹⁾⁽²⁾⁽³⁾ and caffeine⁽⁴⁾⁽⁵⁾ have a positive effect on weight loss on their own. Supplementation with either one of them results in decreases in body mass index, waist circumference and total cholesterol.

Several scientific studies⁽⁶⁾⁽⁷⁾ show that the combination of EGCG and caffeine is even more effective. The combination increases fat burning at rest by 180 kcal⁽⁸⁾ and leads to improvements in body composition and reduces abdominal fatness.⁽⁹⁾

During a meta study, scientists of the University of Connecticut put together and analyzed overall data of 15 studies.⁽¹⁰⁾ They concluded that fat burning is stimulated by combining green tea with caffeine:

First of all, phenols in green tea slow down the enzymes that break down adrenaline and noradrenaline. Increased levels of these substances stimulate the transport of fat cells in the blood, making it easier for the muscles and organs to break them down. On a cellular level, phenols produce a similar effect. The phenols found in green tea, e.g. EGCG, stimulate the mitochondria in the cells to burn more fatty acids, and caffeine makes the cells to react better to adrenaline and green tea. A dose of 150mg of caffeine increases fat burning by 33 percent. Adding 210mg of EGCG (the most active polyphenol in green tea) even increases fat burning up to 41 percent! SynTech™ uses a mega dose of 1330mg of green tea (standardized at 15%) in order to reach the daily dose of 200 mg of EGCG. Anhydro-X contains 320mg caffeine per daily dose.

Capsicum Annuum

Capsicum annuum is an extract of Red Pepper. The active compound is called capsaicin. Studies have showed that Transient Receptor Potential Vanilloid 1 plays an important role in weight loss. Capsaicin activates the TRPV1 receptors, which causes white fat cells to start burning energy instead of storing it.

During a clinical study carried out by the University of Oklahoma, capsicum annuum was administered to a group of people 60 minutes before they were asked to do physical exercises. Compared to another group that got a placebo, the people of the first group turned out to burn 278 calories more before, during and after the physical effort.

This study confirms findings other research: capsicum annuum intake improves thermogenesis⁽¹¹⁾ and enhances the energy expenditure and therefore is an important factor leading to weight loss⁽¹²⁾, abdominal fat decrease⁽¹³⁾ and visceral fat remodeling.⁽¹⁴⁾ Each daily serving contains 200mg capsicum annuum.

EnXtra™

EnXtra is an extract of Alpinia Galanga that’s being harvested in India. It’s also called Blue Ginger. It improves alertness and focus upto 5 hours and amplifies caffeine benefits without having a “crash”.⁽¹⁵⁾

Curcumin

Curcumin is the active compound of the Curcuma Longa plant extract, also known as turmeric. It has a wide variation of benefits. One of them is that in inhibits the enzyme 11-beta-HSD1 in fat cells.⁽¹⁶⁾ This enzyme is needed to activate cortisol. This stress hormone plays a role with the growth of fat deposits, so the less you have, the better. In addition, curcumin inhibits the molecular fat sensor PPAR-gamma in fat cells, making it more difficult for the fat cells to absorb nutrients from the bloodstream.⁽¹⁷⁾

Olive Leaf

The active ingredient in the olive leaf extract is called oleuropein, which increases insulin sensitivity. New Zealand researches of the University of Auckland conducted a study with 46 healthy men who consumed 51mg of Oleuropein per day for 12 weeks. Their result of supplementation with olive leaf extract was that it limited the rise in both glucose and insulin levels after glucose administration. So insulin sensitivity improved, which means the body needs less insulin to control blood sugar levels and fat cells will take up less glucose. Improved insulin sensitivity also means that the breakdown of fat in adipose tissue is not inhibited.  

Vitamin B3 & B6

These vitamins contribute to normal energy-yielding metabolism and to the reduction of tiredness and fatigue. Vitamin B6 also contributes to normal protein and glycogen metabolism.

Chromium

Chromium contributes to the maintenance of normal blood glucose levels and to normal macronutrient metabolism.This plays an important role in weight management.

Piper Nigrum

This Black Pepper extract improves the absorption in the blood of the other ingredients. It is standardized at 95% piperine. Recent research also shows that black pepper has appetite-reducing properties.⁽¹⁸⁾

/// TYPICAL NUTRITIONAL VALUE

/// INGREDIENTS

Camellia Sinensis (Green Tea), Vegetal Capsule (E464), Olea Europeaea (Olive), Filler (Microcrystalline Cellulose), Alpinia Galanga (EnXtra™ Blue Ginger), Gelling Agent (Magnesiumstearate), Caffeine Anhydrous, Capsicum Annuum (Red Pepper), Curcuma Longa L. (Curcuma), Anti-Caking Agent (Silicondioxide), Nicotinamide (Vitamin B3), Piper Nigrum (Black Pepper), Pyridoxine Hydrochloride (Vitamin B6), Chromium Picolinate

/// SCIENTIFIC REFERENCES

1. Auvichayapat P et al. Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial. Physiol Behav. 2008 Feb 27;93(3):486-91.

2. Suliburska J et al. Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients. Biol Trace Elem Res. 2012 Dec;149(3):315-22.

3. Chen IJ et al. Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial. Clin Nutr. 2016 Jun;35(3):592-9.

4. Davoodi SH et al. Caffeine treatment prevented from weight regain after calorie shifting diet induced weight loss. Iran J Pharm Res. 2014 Spring;13(2):707-18.

5. Schubert MM et al. Caffeine consumption around an exercise bout: effects on energy expenditure, energy intake, and exercise J Appl Physiol (1985). 2014 Oct 1;117(7):745-54.

6. Hursel R et al. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes (Lond). 2009 Sep;33(9):956-61.

7. Carper J. Safe stack to lose weight: 300 milligram of EGCG and 300 milligram of caffeine/day. Ergogenics.org. 2006 Oct.

8. Bérubé-Parent S et al. Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men. Br J Nutr. 2005 Sep;94(3):432-6.

9. Wang H et al. Effects of catechin enriched green tea on body composition. Obesity (Silver Spring). 2010 Apr;18(4):773-9.

10. Phung OJ et al. Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis. Am J Clin Nutr. 2010 Jan;91(1):73-81.

11. Galgani JE, Ravussin E. Effect of dihydrocapsiate on resting metabolic rate in humans. Am J Clin Nutr. 2010 Nov;92(5):1089-93.

12. Inoue N et al. Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids). Biosci Biotechnol Biochem. 2007 Feb;71(2):380-9.

13. Snitker S et al. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr. 2009 Jan;89(1):45-50.

14. Jian Chen et al. Activation of TRPV1 channel by dietary capsaicin improves visceral fat remodeling through connexin43-mediated Ca²⁺ Cardiovasc Diabetol. 2015; 14: 22.

15. https://enovatebiolife.com/our-range/enxtra/
16. Gio-Xin HU et al. Curcumin as a Potent and Selective Inhibitor of 11β-Hydroxysteroid Dehydrogenase 1. PLoS One. 2013; 8(3): e49976.
17. Yun K Lee et al. Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells. J Agric Food Chem. 2009 Jan 14;57(1):305-10.
18. Zanzer YC et al. Black pepper-based beverage induced appetite-suppressing effects without altering postprandial glycaemia, gut and thyroid hormones or gastrointestinal well-being: a randomized crossover study in healthy subjects. Food Funct. 2018 May 23;9(5):2774-2786.