Synedrine

/// PRODUCT DESCRIPTION

Synedrine is a fat burner and one of the most advanced of its kind on the market. It is based on extensive scientific research on fat burning and weight management. During the development phase of Synedrine, three requirements were met:

1. The fat burner needs to be effective and has to be based on scientific research

2. It has to meet the strictest health and food safety requirements

3. Synedrine should not make you feel like your heart is racing

The human body has two types of fat, Brown Adipose Tissue, or brown fat, and White Adipose Tissue, or white fat. The main function of brown fat is to turn food into body heat and is often referred as the “good” fat as it burns calories. This process of energy creating is called thermogenesis. White fat cells on the contrary, are the result of excess calorie intake and are storing energy. We typically find these white cells in the waist and thigh area. White fat cells can convert in brown fat cells and also start to burn energy instead of storing it. Synedrine contains a blend of 7 synergistically interacting ingredients which increase fat burning.

Suited for:

• Persons that want to reduce their fat percentage

• Athletes that need to lose weight due to weight categories in their sport

• Body builders during prep- and depletion phase

• Overweight or obese persons that want to change their body composition

/// RECOMMENDED USE

On Training Days: take 2 caps (=1 serving) in the morning on an empty stomach and 2 caps +/- 20 minutes before your workout.

On Non-Training days: take 2 caps in the morning on an empty stomach and 2 caps in the early afternoon (contains 317mg Caffeine).

/// ACTIVE INGREDIENTS PER DAILY SERVING (4 Vcaps)

EGCG (extracted from Green Tea) and Caffeine (extracted from Guarana)

Both the catechin Epigallocatechin Gallate (EGCG)⁽¹⁾⁽²⁾⁽³⁾ and caffeine⁽⁴⁾⁽⁵⁾ have a positive effect on weight loss on their own. Supplementation with either one of them results in decreases in body mass index, waist circumference and total cholesterol.

Several scientific studies⁽⁶⁾⁽⁷⁾ show that the combination of EGCG and caffeine is even more effective. The combination increases fat burning at rest by 180 kcal⁽⁸⁾ and leads to improvements in body composition and reduces abdominal fatness.⁽⁹⁾

During a meta study, scientists of the University of Connecticut put together and analyzed overall data of 15 studies.⁽¹⁰⁾ They concluded that fat burning is stimulated by combining green tea with caffeine:

First of all, phenols in green tea slow down the enzymes that break down adrenaline and noradrenaline. Increased levels of these substances stimulate the transport of fat cells in the blood, making it easier for the muscles and organs to break them down. On a cellular level, phenols produce a similar effect. The phenols found in green tea, e.g. EGCG, stimulate the mitochondria in the cells to burn more fatty acids, and caffeine makes the cells to react better to adrenaline and green tea. A dose of 150mg of caffeine increases fat burning by 33 percent. Adding 210mg of EGCG (the most active polyphenol in green tea) even increases fat burning up to 41 percent! SynTech™ uses a mega dose of 1400mg of green tea (standardized at 15%) in order to reach the daily dose of 210 mg of EGCG. Synedrine contains 1440mg guarana to reach 315mg of caffeine per daily dose. Guarana is used as a caffein source, as it releases caffeine slowly. This way it produces a long-lasting energy plateau and prevents over-excited heart beats.

Capsicum Annuum

Capsicum annuum is an extract of Red Pepper. The active compound is called capsaicin. Studies have showed that Transient Receptor Potential Vanilloid 1 plays an important role in weight loss. Capsaicin activates the TRPV1 receptors, which causes white fat cells to start burning energy instead of storing it.

During a clinical study carried out by the University of Oklahoma, capsicum annuum was administered to a group of people 60 minutes before they were asked to do physical exercises. Compared to another group that got a placebo, the people of the first group turned out to burn 278 calories more before, during and after the physical effort.

This study confirms findings other research: capsicum annuum intake improves thermogenesis⁽¹¹⁾ and enhances the energy expenditure and therefore is an important factor leading to weight loss⁽¹²⁾, abdominal fat decrease⁽¹³⁾ and visceral fat remodeling.⁽¹⁴⁾ Each daily serving contains 200mg capsicum annuum.

Svetol®

Svetol® is a extract of decaffeinated green coffee and has a considerable effect on fat burning. It reduces the body mass index (BMI), regulates blood sugar levels and increases lean muscle mass after 60 days. This was one of the conclusions from a clinical study carried out by the manufacturer in cooperation with the INRA, the French National Institute for Agricultural Research.⁽¹⁵⁾

Svetol® consists for about 50% of chlorogenic acid. Chlorogenic acids are polyphenols which have antioxidant effects and have been proven to be very effective for losing weight. According to the study, the recommended daily intake is 400mg, to be taken in one or several doses. According to another study published in Phytothérapie⁽¹⁶⁾, volunteers with overweight problems who used Svetol®, lost 5kg on average over 60 days. Synedrine contains 400mg per daily serving.

Taraxacum Officinale

Taraxacum officinale is a Dandelion plant extract with diuretic properties. It helps to release excessive water⁽¹⁷⁾ and helps to define and shape your muscles. Each daily serving contains 210mg.

Forslean®

Forslean® is the patented extract of Coleus Forskohlii (standardized at 10% of forskolin). Forslean® stimulates the body to convert existing white fat tissue into metabolically active brown fat by increasing cAMP levels.⁽¹⁸⁾ Cyclic Adenosine Monophosphate is an intracellular signaling molecule (also called a “second messenger”) which plays an important role in several biological processes, including the regulation of glycogen, sugar and lipolysis.⁽¹⁹⁾⁽²⁰⁾ Each daily serving contains 250mg.

Piper Nigrum

This Black Pepper extract improves the absorption in the blood of the other ingredients. It is standardized at 95% piperine. Recent research also shows that black pepper has appetite-reducing properties.⁽²¹⁾

/// TYPICAL NUTRITIONAL VALUE

/// INGREDIENTS

Paullinia Cupana (Guarana), Camellia Sinensis (Green Tea), Vegetal Capsule (E464), Coffea Cannephora Robusta P (Svetol® Green Coffee Bean), Coleus Forskohlii (Forslean® Coleus), Taraxacum Officinale (Dandelion), Capsicum Annuum (Red Pepper) , Gelling Agent (Magnesiumstearate), Piper Nigrum (Black Pepper), Anti-Caking Agent (Silicondioxide)

/// SCIENTIFIC REFERENCES

1. Auvichayapat P et al. Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial. Physiol Behav. 2008 Feb 27;93(3):486-91.

2. Suliburska J et al. Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients. Biol Trace Elem Res. 2012 Dec;149(3):315-22.

3. Chen IJ et al. Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial. Clin Nutr. 2016 Jun;35(3):592-9.

4. Davoodi SH et al. Caffeine treatment prevented from weight regain after calorie shifting diet induced weight loss. Iran J Pharm Res. 2014 Spring;13(2):707-18.

5. Schubert MM et al. Caffeine consumption around an exercise bout: effects on energy expenditure, energy intake, and exercise J Appl Physiol (1985). 2014 Oct 1;117(7):745-54.

6. Hursel R et al. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes (Lond). 2009 Sep;33(9):956-61.

7. Carper J. Safe stack to lose weight: 300 milligram of EGCG and 300 milligram of caffeine/day. Ergogenics.org. 2006 Oct.

8. Bérubé-Parent S et al. Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men. Br J Nutr. 2005 Sep;94(3):432-6.

9. Wang H et al. Effects of catechin enriched green tea on body composition. Obesity (Silver Spring). 2010 Apr;18(4):773-9.

10. Phung OJ et al. Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis. Am J Clin Nutr. 2010 Jan;91(1):73-81.

11. Galgani JE, Ravussin E. Effect of dihydrocapsiate on resting metabolic rate in humans. Am J Clin Nutr. 2010 Nov;92(5):1089-93.

12. Inoue N et al. Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids). Biosci Biotechnol Biochem. 2007 Feb;71(2):380-9.

13. Snitker S et al. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr. 2009 Jan;89(1):45-50.

14. Jian Chen et al. Activation of TRPV1 channel by dietary capsaicin improves visceral fat remodeling through connexin43-mediated Ca²⁺ Cardiovasc Diabetol. 2015; 14: 22.

15. Nardon K et al. Green coffee extract Svetol® can manage weight: a review. Agro Food Industry Hi-Tech. 2007 Sept;18(5):37-39.

16. Dellalibera O, Lemaire B, Lafay S. Svetol®, green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem. Phytothérapie. 2006 Nov;4(4):194-197.

17. Clare BA et al. The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day. J Altern Complement Med. 2009 Aug;15(8):929-34.

18. Sabinsa Corporation. https://forslean.com/ip-rights and https://forslean.com/forslean/mechanism. 

19. Tsuguyoshi A. Clinical report on root extract of perilla plant (Coleus forskohlii) ForsLean® in reducing body fat. Asano Institute. 2001. Tokyo, Japan.

20. Kreider RB et al. Effects of Coleus forskohlii supplementation on body Composition and Hematological Profiles in Mildly Overweight Women. J Int Soc Sports Nutr. 2005; 2(2): 54–62.

21. Zanzer YC et al. Black pepper-based beverage induced appetite-suppressing effects without altering postprandial glycaemia, gut and thyroid hormones or gastrointestinal well-being: a randomized crossover study in healthy subjects. Food Funct. 2018 May 23;9(5):2774-2786.