SynFlex

/// PRODUCT DESCRIPTION

These days people live a more active and healthy lifestyle. We are encouraged to exercise more, practice sports and move more in general. We take protein for our muscles, NO products for better performance, but we forget that because we exercise more, we put more stress on our joints and skeletal system, and joints can wear out.

SynTech developed a sophisticated formula for joints, connective tissue and cartilage that improves mobility and keeps your joints flexible.

SynFlex is a high-end formulation for connective tissues that are a component of bone, ligaments (that serve to hold bones together in proper articulation at the joints), tendons (that attach muscles to bones) and cartilage (that connects bones together and is found in joints and intervertebral discs). To upgrade the formula, Copper and Vitamin C were added. Copper contributes to maintenance of normal connective tissues and vitamin C contributes to normal collagen formation for the normal function of bones and cartilage.

Suited for:

• Sportsmen and women with injuries related to joints, ligaments and cartilage

• Persons with joint or ligament problems

• Persons with knee injuries or chronic knee pain

• Persons with arthrosis or osteoarthritis

/// RECOMMENDED USE

Take 3 caps (=1 serving) per day with a meal, every day of the week.

/// ACTIVE INGREDIENTS PER DAILY SERVING (3 Vcaps)

Glucosamine

Glucosamine is a naturally occurring substance found in connective tissues of the body. It plays an important role in developing, repairing and maintaining cartilage within the joints. Glucosamine is known to inhibit the breakdown of cartilage associated with osteoarthritis and helps build-up cartilage.⁽¹⁾⁽²⁾⁽³⁾ Additionally it has shown anti-inflammatory effects, for as well people who have knee pain as athletes that have a knee injury.⁽⁴⁾ D-glucosamine hydrochloride is used, as it is better absorbed by the body than the sulfate form. Each serving contains 1500mg active glucosamine.

Chondroitin

Chondroitin sulfate is also naturally found in connective tissues. It is combined with glucosamine as it has similar anti-inflammatory effects and also inhibits the breakdown of cartilage associated with (knee) osteoarthritis.⁽⁵⁾ Each serving contains 500mg active chondroitin.

Methyl Sulfonyl Methane (MSM)

MSM is a sulphur-containing compound naturally occurring in plants, animals and humans. It can be found in small amounts in for example fruit, tomato, cowmilk, coffee, and tea. As a food supplement, MSM may help reduce joint pain and has anti-inflammatory effects.⁽⁵⁾ It works synergistically with glucosamine and chondroitin. The combination has proved to be more efficient than the substances alone.⁽⁶⁾ A pilot study specially done on athletes shows that MSM may help reduce muscle soreness and speed up recovery after training.⁽⁷⁾ Each serving contains 500mg MSM.

Curcumin

Curcumin is the active compound of the Curcuma Longa plant extract, also known as turmeric. It has a wide variation of benefits, for example brain health and its anti-inflammatory effects. It is a powerful antioxidant that addresses the cause of joint sensitivity. Curcumin contributes to the maintenance of flexible joints, muscles and tendons and also helps to prevent and limit cartilage ageing.⁽⁸⁾⁽⁹⁾ SynFlex contains 100mg Curcumin.

Peptan® Collagen

Peptan are bioactive collagen peptides that are produced by the enzymatic hydrolysis of pure collagen protein. It are the same type of peptides found in our bones and skin. Peptan is easily digestible by the human body, highly bioavailable and highly bioactive. Hydrolyzed collagen offers multiple benefits linked to athletic performance⁽¹º⁾ and joint mobility.⁽¹¹⁾⁽¹²⁾ Each serving contains 40mg Peptan.

Vitamin C

This antioxidant has shown positive effects on knee cartilage and bones in the context of osteoarthritis.⁽¹³⁾  Vitamin C contributes to normal collagen formation for the normal function of bones and cartilage.⁽¹⁴⁾ Each serving contains 15mg.

Copper

Copper is an essential mineral that the body requires in small amounts. It can be found in nuts and seeds, spinach, lobster and mushroom. It has several health benefits⁽¹⁵⁾⁽¹⁶⁾, for example the function of immune system, but specifically for SynFlex, copper contributes to the maintenance of connective tissue.⁽¹⁷⁾  Each serving contains 15% of the daily reference intake.

/// TYPICAL NUTRITIONAL VALUE

/// INGREDIENTS

D-Glucosamine Hydrochloride (Crustaceans), Chondroitin Sulfate Sodium (Crustaceans, Fish), MSM (Methyl Sulfonyl Methane), Vegetal Capsule (E464), Filler (Microcrystalline Cellulose), Curcuma Longa L. (Curcuma), Bovine Collagen Peptides (Peptan®), Gelling Agent (Magnesiumstearate), Anti-Caking Agent (Siliciumdioxide), Ascorbic Acid (Vitamin C), Copper Gluconate

/// SCIENTIFIC REFERENCES

1. Herrero-Beaumont et al. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms. Arthritis Rheum. 2007 Feb; 56(2):555-67.

2. Pavelká et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis. Arch Intern Med. 2002 Oct 14; 162(18):2113-23.

3. Momomura et al. Evaluation of the effect of glucosamine administration on biomarkers of cartilage and bone metabolism in bicycle racers. Mol Med Rep. 2013 Mar; 7(3):742-6.

4. Ostojic et al. Glucosamine administration in athletes: effects on recovery of acute knee injury. Res Sports Med. 2007 Apr-Jun; 15(2):113-24.

5. Lubis et al. Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis. Acta Med Indones. 2017 Apr;49(2):105-111.

6. Usha PR, Naidu MU. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. 2004;24(6):353-63.

7. Kalman et al. Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study. J Int Soc Sports Nutr. 2012 Sep 27;9(1):46.

8. Hatefi et al. Effects of curcumin on bone loss and biochemical markers of bone turnover in patients with spinal cord injury. World Neurosurg. 2018 Jun;114:e785-e791.

9. Mantzorou et al. Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data. Phytother Res. 2018 Jun;32(6):957-975.

10. Clark et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr red Mes Opin. 2008. 24:1485-1496.

11. Kumar et al. A double-blind, pacebo-controlled, randomised clinical study on the effectiveness of collagen peptides on osteoarthritis. J Sci Food Agric. 2015 Mar 15; 95(4):702-7.

12. Rousselot BV. https://www.peptan.com/science.

13. Wang et al. Effect of antioxidants on knee cartilage and bone in healthy, middle-aged subjects: a cross-sectional study. Arthritis Res Ther. 2007;9(4):R66.

14. European Food Safety Authority. Vitamin C contributes to normal collagen formation for the normal function of bones and cartilage. EFSA Journal 2009; 7(9):1226.

15. European Food Safety Authority. Copper contributes to the normal function of the immune system. EFSA Journal 2009; 7(9):1211.

16. European Food Safety Authority. Copper contributes to the protection of cells from oxidative stress. EFSA Journal 2009; 7(9):1211.

17. European Food Safety Authority. Copper contributes to maintenance of normal connective tissues. EFSA Journal 2009; 7(9):1211.